Drs. Druker, List and Prives join Aileron’s pioneering efforts to advance its stapled peptide approach to restoring p53’s cancer-fighting function
CAMBRIDGE, Mass., March 28, 2018 (GLOBE NEWSWIRE) -- Aileron Therapeutics (NASDAQ:ALRN), the clinical-stage leader in the field of stapled peptide therapeutics for cancers and other diseases, today announced that three leading oncology experts have joined its Scientific Advisory Board (SAB).
“We are honored that world-class scientists and physicians with the accomplishments of Drs. Druker, List and Prives are joining our advisory board,” commented Joseph A. Yanchik III, President and CEO of Aileron. “Aileron’s mission is to develop solutions for patients utilizing a groundbreaking drug platform to target what are believed to be undruggable targets and cellular functions. In order to achieve our mission, we need to be successful in enlisting experts with a track record of breakthrough science and drug development as we have done with these new advisors.”
The additions to Aileron’s SAB include:
“The additions of high-caliber advisors to our existing Scientific Advisory Board, which is chaired by preeminent researchers like Dr. Michael Kastan at Duke Cancer Center and Dr. Loren Walensky at Dana-Farber, underscores our commitment to the development of innovative cancer therapeutics,” said Manuel Aivado, M.D., Ph.D., Chief Medical and Scientific Officer of Aileron. “We are committed to the discovery of transformative treatments for patients with a wide variety of cancers starting with ALRN-6924, a first of its kind stapled peptide therapeutic targeting MDMX and MDM2, the primary suppressors of p53 which is one of the most sought-after cancer drug targets.”
About ALRN-6924
ALRN-6924 is a first-in-class product candidate designed to reactivate wild type p53 tumor suppression by disrupting the interactions between the two primary p53 suppressor proteins, MDMX and MDM2. Aileron believes ALRN-6924 is the first and only product candidate in clinical development that can equipotently bind to and disrupt the interaction of MDMX and MDM2 with p53. Based on preclinical data and preliminary evidence of safety and anti-tumor activity in its ongoing clinical trials, there may be a significant opportunity to develop ALRN-6924 as a monotherapy or combination therapy for a wide variety of solid and liquid tumors. ALRN-6924 is currently being evaluated in multiple clinical trials for the treatment of acute myeloid leukemia (AML), advanced myelodysplastic syndrome (MDS) and peripheral T-cell lymphoma (PTCL). For information about its clinical trials, please visit www.clinicaltrials.gov.
About Aileron
Aileron is a clinical-stage biopharmaceutical company advancing stapled peptides, a novel class of therapeutics for cancers and other diseases. Stapled peptides are chemically stabilized alpha-helical peptides that are modified to improve their stability and cell penetrability while maintaining high affinity for large protein surfaces. Our goal is to use our proprietary stapled peptide drug platform to create first-in-class therapeutics, like ALRN-6924, that may be able to address historically undruggable targets and complex mechanisms that underlie many diseases with high unmet medical need. Our platform enables us to chemically stabilize and improve the performance and activity of a broad range of alpha-helical peptides that we believe can potentially activate and inhibit key cellular functions that are otherwise difficult to target with existing drug technologies, including small molecules and monoclonal antibodies. For more information, visit www.aileronrx.com.
Forward-looking Statements
Statements in this press release about Aileron's future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including whether Aileron’s cash resources will be sufficient to fund its continuing operations for the period anticipated; whether results obtained in preclinical studies and clinical trials will be indicative of results obtained in future clinical trials; whether Aileron’s product candidates will advance through the clinical trial process on a timely basis, or at all; whether the results of such trials will warrant submission for approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether Aileron's product candidates will receive approval from regulatory agencies on a timely basis or at all; whether, if product candidates obtain approval, they will be successfully distributed and marketed; and other factors discussed in the "Risk Factors" section of Aileron's quarterly report on Form 10-Q for the period ended September 30, 2017, filed on November 9, 2017, and risks described in other filings that Aileron may make with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Aileron specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.
Source: Aileron Therapeutics
Contacts: Investors Aileron Therapeutics Don Dougherty, CFO 617-995-0900 [email protected] Media BMC Communications Brad Miles, 646-513-3125 [email protected]
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