Seattle Genetics, Inc. (Nasdaq:SGEN) today reported financial results for the fourth quarter and year ended December 31, 2018. The company also highlighted ADCETRIS (brentuximab vedotin) commercialization and clinical development accomplishments and progress with its late-stage clinical programs for cancer.
“During 2018, we received FDA approval for two ADCETRIS frontline indications, a major accomplishment that significantly expands the number of patients eligible to benefit from treatment. These approvals for frontline advanced Hodgkin lymphoma and CD30-expressing peripheral T-cell lymphoma (PTCL) were based on phase 3 data showing superior efficacy of the ADCETRIS-containing regimens compared to combination chemotherapy agents that have been used for decades,” said Clay Siegall, Ph.D., President and Chief Executive Officer of Seattle Genetics. “Additionally, we made progress in 2018 with our late-stage clinical programs, leading to important anticipated milestones this year. Notably, we expect to report top-line data in the first quarter of 2019 from the pivotal trial of enfortumab vedotin in metastatic urothelial cancer and to report top-line data later in the year from the pivotal trial of tucatinib in HER2-positive metastatic breast cancer. Taken together, we are positioned to establish ADCETRIS as the standard of care in the frontline setting in both advanced Hodgkin lymphoma and CD30-expressing PTCL, and realize our vision of becoming a company with multiple oncology products addressing unmet medical needs.”
ADCETRIS Program Highlights
Enfortumab Vedotin (EV) Program Highlights
Tucatinib Program Highlights
Tisotumab Vedotin (TV) Program Highlights
Other Recent Activities
FOURTH QUARTER AND FULL YEAR 2018 FINANCIAL RESULTS
Revenues: Total revenues in the fourth quarter and year ended December 31, 2018 increased to $174.5 million and $654.7 million, respectively, compared to $129.6 million and $482.3 million for the same periods in 2017. Revenues are comprised of the following three components:
Research and Development (R&D) Expenses: R&D expenses in the fourth quarter were $149.8 million, compared to $110.5 million in the fourth quarter of 2017. R&D expenses were $565.3 million for the full year in 2018, compared to $456.7 million for the same period in 2017. The increase in 2018 reflects increased investment in the company's late-stage pipeline and technology acquisition costs in the first quarter of 2018.
Selling, general and administrative (SG&A) Expenses: SG&A expenses in the fourth quarter were $79.5 million, compared to $48.5 million in the fourth quarter of 2017. The increase in SG&A expenses for the fourth quarter of 2018 was primarily driven by the rapid approval and launch of ADCETRIS for frontline CD30-expressing PTCL. SG&A expenses were $261.1 million for the full year in 2018, compared to $167.2 million for the same period in 2017. The increase for the full year in 2018 was primarily related to costs to support the launch of ADCETRIS in the frontline indications as well as transaction costs associated with the acquisition of Cascadian Therapeutics.
Cost of Sales: Cost of sales in the fourth quarter were $30.2 million, compared to $10.2 million in the fourth quarter of 2017. Cost of sales were $66.1 million for the year in 2018, compared to $34.8 million for the same period in 2017. The increases in 2018 reflect an inventory write-off of $18.1 million recorded in the fourth quarter of 2018 related to in-process production that did not meet manufacturing specifications and did not impact availability of product supply required to meet demand for ADCETRIS.
Non-cash, share-based compensation cost for the full year in 2018 was $78.9 million, compared to $63.8 million for the same period in 2017.
Net Loss: Net loss for the fourth quarter of 2018 was $119.8 million, or $0.75 per share, compared to a net loss of $59.2 million, or $0.41 per share, for the fourth quarter of 2017. Net loss in the fourth quarter of 2018 includes a net investment loss of $53.2 million primarily associated with Seattle Genetics’ common stock holdings in Immunomedics, which are marked-to-market. For the full year in 2018, net loss was $222.7 million, or $1.41 per share, compared to a net loss of $125.5 million, or $0.88 per share, for the year in 2017. Net loss for the full year in 2018 includes net investment income of $13.7 million primarily associated with Seattle Genetics’ common stock holdings in Immunomedics. Net loss for both the fourth quarter and the full year in 2018 included a non-cash income tax benefit of $23.7 million related to acquired intangible assets as part of the acquisition of Cascadian Therapeutics.
Cash and Investments: As of December 31, 2018, Seattle Genetics had $459.9 million in cash and investments. In addition, the company held stock investments, primarily in Immunomedics common stock, valued at $113.8 million.
2019 FINANCIAL OUTLOOK
Seattle Genetics anticipates 2019 total revenues to be in the range of $790 million to $840 million, driven by the following components:
ADCETRIS net product sales | $610 million to $640 million | ||||
Collaboration and license agreement revenues | $95 million to $110 million | ||||
Royalty revenues | $85 million to $90 million | ||||
Operating expenses and other costs are expected to be within the following ranges for the year in 2019:
R&D expenses | $600 million to $650 million | ||||
SG&A expenses | $280 million to $310 million | ||||
Cost of sales | 5 percent to 6 percent | ||||
Cost of royalty revenues |
Low single digit percent on ex-US sales |
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Non-cash costs (primarily attributable to share based compensation) | $135 million to $145 million | ||||
Conference Call Details
Seattle Genetics’ management will host a conference call and webcast with supporting slides to discuss its fourth quarter and full year 2018 financial results and provide an update on business activities. The event will be held today at 1:30 p.m. Pacific Time (PT); 4:30 p.m. Eastern Time (ET). The live event and supporting slides will be simultaneously webcast on the Seattle Genetics website at www.seattlegenetics.com, under the Investors section. Investors may also participate in the conference call by calling 877-260-1479 (domestic) or 334-323-0522 (international). The conference ID is 1660553. A replay of the live event and supporting slides will be available starting on February 7, 2019 on the Seattle Genetics website at www.seattlegenetics.com, under the Investors section, for at least 30 days. A replay of the audio only will be available by calling 888-203-1112 (domestic) or 719-457-0820 (international), using conference ID 1660553. The telephone replay will be available until 5:00 p.m. PT on February 11, 2019.
About Seattle Genetics
Seattle Genetics, Inc. is an emerging multi-product, global biotechnology company that develops and commercializes transformative therapies targeting cancer to make a meaningful difference in people’s lives. ADCETRIS® (brentuximab vedotin) utilizes the company’s industry-leading antibody-drug conjugate (ADC) technology and is currently approved for the treatment of multiple CD30-expressing lymphomas. Beyond ADCETRIS, the company has established a pipeline of novel targeted therapies at various stages of clinical testing, including three in ongoing pivotal trials for solid tumors. Enfortumab vedotin for metastatic urothelial cancer and tisotumab vedotin for metastatic cervical cancer utilize our proprietary ADC technology. Tucatinib, a small molecule tyrosine kinase inhibitor, is in a pivotal trial for HER2-positive metastatic breast cancer. In addition, we are leveraging our expertise in empowered antibodies to build a portfolio of proprietary immuno-oncology agents in clinical trials targeting hematologic malignancies and solid tumors. The company is headquartered in Bothell, Washington, and has a European office in Switzerland. For more information on our robust pipeline, visit www.seattlegenetics.com and follow @SeattleGenetics on Twitter.
Forward-Looking Statements
Certain of the statements made in this press release are forward looking, such as those, among others, relating to the company’s 2019 outlook, including anticipated 2019 revenues, costs and expenses; the company’s potential to achieve the noted development and regulatory milestones in 2019 and in future periods and to establish ADCETRIS as the standard of care in the frontline setting in both advanced Hodgkin lymphoma and CD30-expressing PTCL and become a multi-product oncology company; anticipated activities related to the company’s planned and ongoing clinical trials, including clinical trial enrollment and data availability and the expected timing thereof, including with respect to EV-201, HER2CLIMB and other clinical trials; the potential for the company’s clinical trials to support further development, regulatory submissions and potential marketing approvals; the opportunities for, and the therapeutic and commercial potential of ADCETRIS, enfortumab vedotin, tucatinib, and tisotumab vedotin and the company’s other product candidates and those of its licensees and collaborators; as well as other statements that are not historical facts. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks that the company’s ADCETRIS net sales, revenue, expense, and other financial guidance may not be as expected, as well as risks and uncertainties associated with maintaining or increasing sales of ADCETRIS due to competition, unexpected adverse events, regulatory action, reimbursement, or market adoption by physicians. The company may also be delayed in its planned clinical trial initiations, the enrollment in and conduct of its clinical trials, obtaining data from clinical trials, planned regulatory submissions, and regulatory approvals in each case for a variety of reasons including the difficulty and uncertainty of pharmaceutical product development, u, negative or disappointing clinical trial results, unexpected adverse events or regulatory discussions or actions and the inherent uncertainty associated with the regulatory approval process. More information about the risks and uncertainties faced by Seattle Genetics is contained under the caption “Risk Factors” included in the company’s periodic reports filed with the Securities and Exchange Commission, including the company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2018 and future periodic reports filed by the company, including the company's Annual Report on Form 10-K for the year ended December 31, 2018.
Seattle Genetics, Inc. | |||||||||||||||||
Condensed Consolidated Statements of Operations | |||||||||||||||||
(Unaudited) | |||||||||||||||||
(In thousands, except per share amounts) | |||||||||||||||||
Three Months Ended December 31, | Year Ended December 31, | ||||||||||||||||
2018 | 2017 | 2018 | 2017 | ||||||||||||||
Revenues: | |||||||||||||||||
Net product sales | $ | 132,127 | $ | 83,721 | $ | 476,903 | $ | 307,562 | |||||||||
Collaboration and license agreement revenues | 17,833 | 25,853 | 94,357 | 108,632 | |||||||||||||
Royalty revenues | 24,553 | 20,031 | 83,440 | 66,056 | |||||||||||||
Total revenues | 174,513 | 129,605 | 654,700 | 482,250 | |||||||||||||
Costs and expenses: | |||||||||||||||||
Cost of sales | 30,222 | 10,213 | 66,085 | 34,768 | |||||||||||||
Cost of royalty revenues | 5,363 | 5,450 | 22,208 | 19,350 | |||||||||||||
Research and development | 149,772 | 110,504 | 565,309 | 456,700 | |||||||||||||
Selling, general and administrative | 79,467 | 48,450 | 261,096 | 167,233 | |||||||||||||
Total costs and expenses | 264,824 | 174,617 | 914,698 | 678,051 | |||||||||||||
Loss from operations | (90,311 | ) | (45,012 | ) | (259,998 | ) | (195,801 | ) | |||||||||
Investment and other income (loss), net | (53,180 | ) | (42,131 | ) | 13,652 | 36,914 | |||||||||||
Loss before income taxes | (143,491 | ) | (87,143 | ) | (246,346 | ) | (158,887 | ) | |||||||||
Income tax benefit | 23,686 | 27,942 | 23,653 | 33,357 | |||||||||||||
Net loss | $ | (119,805 | ) | $ | (59,201 | ) | $ | (222,693 | ) | $ | (125,530 | ) | |||||
Net loss per share - basic and diluted | $ | (0.75 | ) | $ | (0.41 | ) | $ | (1.41 | ) | $ | (0.88 | ) | |||||
Shares used in computation of per share amounts - basic and diluted | 160,197 | 144,061 | 157,655 | 143,174 | |||||||||||||
Seattle Genetics, Inc. | |||||||
Condensed Consolidated Balance Sheets | |||||||
(Unaudited) | |||||||
(In thousands) | |||||||
December 31, | |||||||
2018 | 2017 | ||||||
Assets | |||||||
Cash, cash equivalents and investments | $ | 459,866 | $ | 413,171 | |||
Other assets | 1,043,463 | 464,778 | |||||
Total assets | $ | 1,503,329 | $ | 877,949 | |||
Liabilities and Stockholders’ Equity | |||||||
Accounts payable and accrued liabilities | $ | 191,472 | $ | 132,672 | |||
Deferred revenue and long-term liabilities | 37,914 | 67,708 | |||||
Stockholders’ equity | 1,273,943 | 677,569 | |||||
Total liabilities and stockholders’ equity | $ | 1,503,329 | $ | 877,949 |
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